ACEP 2014 – Revenge of the Nerds

ACEP 2014 – Revenge of the Nerds

Oh Henry

From the exhibit floor to the council meeting, musings on emergency medicine’s biggest circus

ACEP Takes Second Swing at ‘Choosing Wisely’

ACEP Takes Second Swing at ‘Choosing Wisely’

Rick's Reviews

ACEP's obvious list confronts practice variation

Poppers, Meet Methylene Blue

Poppers, Meet Methylene Blue

Tox Call

'Poppers' proliferate, but methylene blue proves surprisingly effective

Typical Eye Irritation? Don’t Miss This

Typical Eye Irritation? Don’t Miss This

Visual Dx

Presentations can vary, but urgent diagnosis is always essential

Rule #1– Don’t Yell Back

Rule #1– Don’t Yell Back

Director's Corner

A nurse just yelled at you at the nurses station. What you do next could is critical

Bradycardic and Blue

Bradycardic and Blue

Soundings

How bedside ultrasound can help bring a crashing patient into focus

ED Throughput: A Fixable Problem

ED Throughput: A Fixable Problem

Rick's Reviews

Two recent studies give practical steps for shortening the wait in the emergency department

Facing MRSA? Look Beyond Vancomycin

Facing MRSA? Look Beyond Vancomycin

The Rx Pad

With recent vancomycin shortages, it’s important to know what other drugs can be used to treat MRSA

Greg Henry Talks Workforce on the ACEP Floor

Greg Henry Talks Workforce on the ACEP Floor

Video

EPM teamed up with MedPage Today to bring readers a series of interviews with EM thought leaders

What’s It All About?

What’s It All About?

Oh Henry

Give me residents who are more than their CVs, doctors who base their practice on actual beliefs and values

In Search of a Safe Harbor

In Search of a Safe Harbor

Changemakers

Could bipartisan bill finally cut healthcare costs by reducing defensive medicine?

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Schizophrenia, the most common psychotic disorder, affects 1 percent of the general population.  The symptoms begin in late adolescence or early 20s in men and 20s and early 30s in women.  The DSM-IV diagnostic criteria for schizophrenia includes:  at least 6 months of sufficiently deteriorated occupational, interpersonal and self-supportive functioning; two or more of the following positive symptoms: delusions, hallucinations, disorganized speech or behavior; or negative symptoms such as affective flattening, alogia or avolition during a 1 month period.  The symptoms can not be accounted for by the presence of a schizoaffective or major mood disorder, autism, or an organic condition.  Positive and negative symptoms vary in intensity over time.  Criminal behavior is not a characteristic of schizophrenia however, patients may commit violent acts due to their hallucinations, delusions, or impaired social skills.  The lifetime prevalence of suicide is 10 percent amongst schizophrenics.

    Multiple genetic and environmental factors are responsible for the symptoms seen in schizophrenia.  One factor is the dopamine theory in which increased dopaminergic neurotransmission causes psychosis.  By decreasing dopaminergic transmission via antipsychotic drugs, the distractibility seen in schizophrenia decreases and improves perceptual abilities.  The theory has several flaws.  First, symptoms are not fully alleviated by treatment.  Secondly, dopamine levels are within normal ranges before and after treatment.  Thirdly, dopamine and its role in the brain is more complex than acting as a simple switch for psychotic symptoms.  Inhibitory interneurons are also affected by a decrease in their number, in enzymes that synthesize the inhibitory neurotransmitter gamma-aminobutyric acid, in neuropeptides cholecystokinin and somatostatin, and in migration of neurons into the cortex from white matter.  There are also genetic findings such as greater concordance among monozygotic twins than dizygotic twins and the high incidence of schizophrenia among adopted children, whose biologic mothers have schizophrenia.  These findings point to a genetic component that accounts for 70 percent of the risk.  The environmental component accounts for the remaining 30 percent, that includes perinatal and childhood brain injury and psychosocial stressors.

    The pharmacologic approach to schizophrenia and its symptoms is centered on neurotransmitters that control the response of neurons to stimuli.  First generation antipsychotic agents such as haloperidol and chlorpromazine block dopamine D2 receptors.  Twenty percent of patients have complete remission of their symptoms, most patients have some response but with continuing symptoms.  Side effects include involuntary movement disorders arising from the extrapryamidal system.  Symptoms include dystonia, akathisia, bradykinesia and tremor.  Akathisia, a state of restlessness, is a major cause of noncompliance with the drug regimen.  It can be treated with propranolol.  Bradykinesia, slowed voluntary movements can be treated with benzotropine.  Tardive dyskinesia, a choreoathetotic movement disorder, develops in 30 percent of patients after several years of treatment.  Orofacial movements are common manifestations.  It slowly resolves after withdrawal of first generation drugs, although it may be irreversible.  When diagnosed early it is usually reversed with a change in medication.  Temperature dysregulation can lead to neuroleptic malignant syndrome, in which the patient’s temperature exceeds 104°F.  Dantrolene, bromocriptine, and rapid cooling can be used to treat the hyperthermia.  Prolonged QT interval is seen in several antipsychotics, in particular thioridazine. 

    Second generation antipsychotic agents block D2 dopamine receptors (like first generation drugs) however they are less tightly bound and the D2 dopamine receptor antagonism is not the sole therapeutic mechanism.  They include clozapine, risperidone, olanzapine, ziprasidone, quetiapine, ariprazole and amisulpride.  Their efficacy is equivalent or exceeds the first generation drugs particularly with respect to negative symptoms.  Side effects include weight gain, DM, hypercholesterolemia, hyperprolactinemia, and seizures.  Movement disorders, including tardive dyskinesia are decreased with the second generation drugs.  Clozapine was the first second generation drug to be used and it also blocks D1, D4 dopamine receptors and norepinephrine and serotonin receptors.  Agranulocytosis is a serious risk associated with clozapine and patients taking the drug must undergo frequent monitoring of leukocyte counts.  They are also at risk for myocarditis.  Agranulocytosis can lead to fevers, malaise and frequent infections in the schizophrenic patient.  For noncompliant patients there are depot injection preparations available.

    The primary mode of treatment of schizophrenia is pharmacologic.  Supportive psychosocial methods are useful in the long-term treatment of schizophrenia.  If the acutely psychotic schizophrenic is delirious, suicidal or homicidal and/or has no support, the patient needs to be hospitalized.
 
 

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