While on a recent shift in the ED, I was asked a familiar question by a weekend warrior who had suffered an ankle sprain while playing basketball - “What can I do to get back on the court sooner, Doc?” After explaining the usual RICE protocol (Rest, Ice, Compression, Elevation) my persistent patient asked “What else can I do? What about these platelet rich plasma (“PRP”) injections I hear about?”

For a generation of American physicians, the tragic and infamous case of Libby Zion evokes a multitude of feelings. Although the case is best remembered for the enduring effect it had on resident duty hours, for many of us it was the first time that we became familiar with the serotonin syndrome and the seemingly obscure drug interactions that can cause it.