WhiteCoat

Got emphysema, asthma, arthritis, or inflammatory bowel disease? Eat broccoli.

I was forwarded an article that seems boring, but had an interesting catch to it.

You  may not have known this, but denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.

The study showed that in some forms of chronic inflammatory diseases, such as COPD/emphysema, acute respiratory distress syndrome, asthma, rheumatoid arthritis, and inflammatory bowel disease, a chemical reaction within a transcription factor called NRF2 within the cells causes them to be less sensitive to steroid therapy. When study patients with COPD were given either glutathione or sulforaphane, the chemical reaction was reversed and macrophages within the alveoli of the lungs became significantly more responsive to steroids.

One food that is high in both glutathione and sulforaphane is … broccoli.

Did a little extra research on the internet and found that glutathione is also contained in asparagus, potatoes and many green leafy vegetables and that sulforaphane is also contained in cabbage, cauliflower, bok choi, and those same green leafy vegetables.

And … one of the things that depletes glutathione in the body is Tylenol.

Also ran across a study in 2009 showing that the Nrf2 factor also plays a role in Helicobacter pylori infections and that ingestion of broccoli sprouts decreased byproducts of H. pylori infection by 40%.

Makes me wonder whether these chronic inflammatory diseases may have some type of bacteriologic basis.

Now they just have to do a study to find out many people would rather have COPD exacerbations than eat broccoli or green leafy vegetables every day.

5 Responses to “Got emphysema, asthma, arthritis, or inflammatory bowel disease? Eat broccoli.”

  1. Anonymous says:

    “Now they just have to do a study to find out many people would rather have COPD exacerbations than eat broccoli or green leafy vegetables every day.”

    Or just distill it into a daily pill. Like fiber, omega 3, fish oil, etc etc.

  2. They’d rather light up another cig.

  3. SeaSpray says:

    I did read it can cause acne. I love broccoli ..but think of that when I eat it.

    Interesting study.

  4. ATraveller says:

    “Makes me wonder whether these chronic inflammatory diseases may have some type of bacteriologic basis.”

    I’m not a doctor, or medically trained, but the same thought had occurred to me. When you read about how the innate immunesystem goes bananas when it encounters biofilms, and how biofilms are almost impossible to culture or kill – it’d seem to fit.

    http://onlinelibrary.wiley.com/doi/10.1111/j.1574-695X.2010.00706.x/abstract

  5. OptimumHealth says:

    The answer you’re looking for to increase the body’s own production of glutathione is the Nrf2 activator, Protandim. Check out the link to the peer-reviewed research published to date.

    http://www.mylifevantage.com/optimumhealth/protandim-clinicalproof.aspx

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